Wednesday 25 May 2016

difference between normal and cancer cells & Drivers of cancer

DIFFERENCE BETWEEN NORMAL AND CANCER CELLS

There are some important difference between normal and cancer cells

1.  normal cells develop into more distinct cells types with specific functions but cancer cells have many irregular functioning like abnormal division of the cells.

2.  cancer cells have a property to ignore the anti-growth signals which is produced by tumor suppressor genes.due to this they divide continuously into the cells. but normal cells follow the anti-growth signal and due to this reason they control itself.

3. normal cells have a property of self suicide . but cancer cells does not do so.  

4.immune system of the body is able to rectify the system from abnormal or damage cells but some of the cancer cells are able to hide from the immune system.


5.  normal cells have the property of contact inhibition which means that when the normal cells contact with each other then dividing process of the cells is stopped. but in case of the cancer cells 
due to the lack of the contact inhibition they does not stop dividing into cells.

6. normal cells have limited number of dividing. but cancer cells have unlimited dividing of the cells.



DRIVERS OF CANCER

As we know about the three main genes 
1. tumor suppressor genes
2. proto-oncogenes 
3. DNA repair genes

 tumor suppressor genes are responsible to control the growth of the cells. in case of cancer these tumor suppressor genes become altered so that they can not prevent or control the cells division.
these are also involved in the normal cells and responsible to control the growth of the cells. when these genes are altered then they works as a driver for cancer cells.

DNA repair genes are involved in fixing damaged DNA. Cells with changes in these genes tend to develop additional changes in other genes. Together, these changes may cause the cells to become cancerous.








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